The move comes as analysts estimate that Europe's biggest banks will have to reduce staff still further to generate attractive returns after the death of businesses that fuelled profits in recent years.
Barclays, which expanded its investment banking operations headed by Bob Diamond with the purchase of Lehman Brothers' US operations last year and hiring the collapsed bank's European staff, declined to reveal where the job cuts would come.
An official said: “We've begun a process to reduce headcount across some parts of investment banking and investment management to ensure that we're appropriately sized given the current market conditions.